成長ホルモン関連調査研究
成長ホルモン治療研究専門委員会
1992年、協会に集積された患者データを解析して、多くの有用な情報を成長ホルモン治療医師にフィードバックし、今後の治療の参考にしてもらうことを目的として、登録システム小委員会と共同して成長ホルモン治療研究小委員会が設立された。1997年に成長ホルモン治療研究小委員会とターナー症候群GH臨床研究小委員会が改組され以後「治療研究専門委員会」として活動している。
【研究論文】
Kunihiko Hanew, Toshiaki Tanaka, Reiko Horikawa, Tomonobu Hasegawa, Susumu Yokoya:
The current status of 492 adult women with Turner syndrome: a questionnaire survey by the Foundation for Growth Science.
Endocr J 68 (9):1081-1089,2021
Kunihiko H, Toshiaki T, Reiko H, Tomonobu H, Susumu Y,:
Prevalence of diverse complications and its association with karyotypes in Japanese adult women with Turner syndrome－a questionnaire survey by the Foundation for Growth Science－
Endocr J 65(5): 509-519, 2018
Kunihiko Hanew, Toshiaki Tanaka, Reiko Horikawa, Tomonobu Hasegawa, Keinosuke Fujita, Susumu Yokoya:
Women with Turner syndrome are at high risk of lifestyle-related disease ― From questionnaire surveys by the Foundation for Growth Science in Japan
Endocrine Journal 63 (5), 449-456, 2016
Eri Maeda, Takahiro Higashi, Tomonobu Hasegawa, Susumu Yokoya, Takahiro Mochizuki, Tomohiro Ishii, Junko Ito, Susumu Kanzaki, Akira Shimatsu, Koji Takano, Toshihiro Tajima, Hiroyuki Tanaka, Yusuke Tanahashi, Akira Teramoto, Toshiro Nagai, Kunihiko Hanew, Reiko Horikawa, Toru Yorifuji, Naohiro Wada and Toshiaki Tanaka:
Effects of financial support on treatment of adolescents with growth hormone deficiency: a retrospective study in Japan
BMC Health Services Research (2016) 16:602
望月貴博、石井智弘、伊藤純子、神崎 晋、島津 章、高野幸路、田島敏広、田中弘之、棚橋祐典、寺本 明、永井敏郎、羽二生邦彦、東 尚弘、堀川玲子、横谷 進、依藤 亨、和田尚弘、長谷川奉延、田中敏章：
成長ホルモン治療中のターナー症候群におけるエストロゲン補充療法の治療実態と開始時期の基準に
ついて
日本成長学会雑誌 22 No.1: 43-47, 2016
Fujita K, Yokoya S, Fujieda K, Shimatsu A, Tachibana K, Tanaka H, Tanizawa T, Teramoto A, Nishi Y, Hasegawa Y, Hanew K, Horikawa R, Nagai T, Tanaka T.:
Adult height of 258 girls with Turner syndrome on low dose of growth hormone therapy in Japan.
Clin Pediatr Endocrinol 19(3): 63-68, 2010
田中敏章、伊藤純子、神崎 晋、島津 章、田中弘之、寺本 明、永井敏郎、長谷川奉延、羽二生邦彦、藤田敬之助、堀川玲子、向井徳男、和田尚弘、横谷 進：
成長ホルモン分泌不全性低身長症における成長ホルモンによる前思春期の治療開始年齢別治療効果
日本成長学会雑誌 16: 23-29, 2010
Isojima T, Yokoya S, Ito J, Horikawa R, Tanaka T.:
New reference growth charts for Japanese girls with Turner syndrome.
Pediatrics International 51: 709-714, 2009
Isojima T, Yokoya S, Ito J, Horikawa R, Tanaka T.:
Trends in age and anthropometric data at start of growth hormone treatment for girls with Turner syndrome in Japan.
Endocr J 55(6): 1065-1070, 2008
田中敏章、伊藤純子、島津 章、田中弘之、寺本 明、永井敏郎、長谷川奉延、羽二生邦彦、藤田敬之助、堀川玲子、向井徳男、和田尚弘、横谷 進：
年齢別およびSGA児とAGA児における成長ホルモン治療の一年目の効果の比較
日本成長学会雑誌14: 25-30, 2008
Hanew K, Tachibana K, Yokoya S, Fujieda K, Tanaka T, Igarashi Y, Shimatsu A, Tanaka H, Tanizawa T, Teramoto A, Nishi Y, Hasegawa Y, Hizuka N, Hirano T, Fujita K, GH treatment Study Committee, The Foundation for Growth Science, Japan.:
Clinical characteristics, etiologies and pathophysiology of patients with severe short stature with sever GH deficiency: Questionnaire study on the data registered with the Foundation for Growth Science, Japan.
Endocr J 53: 259-265, 2006
Tanaka T, Fujieda K, Yokoya S, Shimatsu A, Tachibana K, Tanaka H, Tanizawa T, Teramoto A, Nagai T, Nishi Y, Hasegawa Y, Hanew K, Fujita K, Horikawa R, Takada G, Miyashita M, Ohno T, Komatsu K.:
No inprobement of adult height in non-growth hormone (GH) deficient short children with GH treatment.
Clin Pediatr Endocrinol 15: 15-21, 2006
Hanew K, Tachibana K, Yokoya S, Fujieda K, Tanaka T, Igarashi Y, Shimatsu A, Tanaka H, Tanizawa T, Teramoto A, Nishi Y, Hasegawa Y, Hizuka N, Hirano T, Fujita K.:
Studies of very severe shot stature with severe GH deficiency: From the data registered with the Foundation for Growth Science.
Endocr J 52: 37-43, 2005
田中敏章、藤枝憲二、羽二生邦彦、西 美和、立花克彦、横谷 進、五十嵐裕、平野岳毅、藤田敬之助、寺本 明、肥塚直美、島津 章、田中弘之、谷澤隆邦、長谷川行洋：
成長ホルモン分泌不全性低身長症における遺伝子組換え成長ホルモン治療による最終身長の正常化の割合
日本小児科学会雑誌105: 546-551, 2001
Tanaka T, Hanew K, Nishi Y, Tachibana K, Yokoya S, Igarashi Y, Hirano T, Fujita K, Saito T, Hizuka N, Shimatsu A, Tanaka H, Tanizawa T, Teramoto A, Fujieda K.:
Final height of growth hormone (GH)-treated short children registered at the Foundation for Growth Science in Japan: Comparison between the pituitary human GH era and the recombinant human GH era.
Clin pediatr Endocrinol 10 (1): 53-62, 2001
Tanaka T, Takano K, Ogawa M, Tachibana K, Fujieda K, Hizuka N and the members of Study Groups of GH treatment of Turner syndrome:
Final height in Turner syndrome after growth hormone treatment: Japanese study.
Optimizing Health Care for Turner Patients in the 21st Century (eds. Saenger P, Albertsson-Wikland K),
Elsevier Science B.V., Amsterdam, pp223-228, 2000
Takano K, Tanaka T, Ogawa M, Tachibana K, Fujita K, Hizuka N and Members of the Committee for the Treatment of Turnerﾕs Syndrome:
Clinical outcome of GH treatment in Turner girls in Japan: results of multicentre trial.
Clin Pediatr Endocrinol 9 (suppl 14): 15-22, 2000
田中敏章、高野和寿恵、羽二生邦彦、西 美和、藤枝憲二、立花克彦、横谷 進、五十嵐裕、平野岳毅、肥塚直美、島津 章、齋藤友博、藤田敬之助：
成長ホルモン分泌不全性低身長症の成長ホルモン治療の頻度－成長科学協会における登録の解析－
ホルモンと臨床 46：1017-1023, 1998
Takano K, Ogawa M, Tanaka T. Tachibana K, Fujita K, Hizuka N.:
Final height in patients with Turner syndrome after treatment with GH.
Clin Pediatr Endocrinol 6 (suppl 10): 51-57, 1997
Takano K, Ogawa M, Tanaka T. Tachibana K, Fujieda K, Hizuka N, and the Members of the Committee for the Treatment of Turnerﾕs Syndrome:
Clinical trials of GH treatment in patients with Turnerﾕs syndrome in Japan-a consideration of final height.
Eur J Endocrinol. 137: 138-145, 1997
Tanaka T. Takano K, Hanew K, Nishi Y, Fujieda K, Tachibana K, Yokoya S, Igarashi Y, Hirano T.:
Spontaneous growth in growth hormone-treated short children.
Endocr J 43 (suppl): S135-S136, 1996
藤枝憲二、田中敏章、立花克彦、高野和寿恵、西 美和、佐々木望、矢野公一、岡部康文、岩松浩子、滝沢鷹太郎、宇佐見郁哉、大元習子、千葉喜代志、伊賀和夫、番場正博：
成長ホルモン療法を行っている糖尿病患者の実態調査
日本小児科学会雑誌100（5）：877-881, 1996
Takano K, Tanaka T, Saito T, the Committee for the Study Group of Adult GH Deficiency:
Psychosocial adjustment in a large cohort adults with growth hormone deficiency treated with growth hormone in childhood: summary of a questionnaire survey.
Acta Pediatr (suppl) 339: 16-19, 1994
Takano K, Tanaka T, Saito T, the Member of the Committee:
Psychosocial consequences of growth hormone deficiency (GHD) in adults.
Clin Pediatr Endocrinol 3 (suppl 5): 79-86, 1994
Takano K, Tanaka T, Saito T, the Members of the Committee of the Study Group for Adult GH Deficiency, Foundation for Growth Science in Japan:
Quality of the life growth hormone treated adults.
Clin Pediatr Endocrinol 3 (suppl 4): 47-53, 1994
Takano K, Shizume K, Hibi I, Ogawa M, Okada Y, Suwa S, Tanaka T, and Members of the Committee for the Treatment of Turner Syndrome:
Growth hormone treatment in Turner syndrome: Results of a multicentre study in Japan.
Home Res 39 (suppl 2): 37-41,1993
田中敏章、日比逸郎、鎮目和夫、Turner症候群GH治療研究会員:
Turner症候群における成長ホルモン（GH）分泌能とGH治療効果の検討－下垂体性小人症との比較－
日本内分泌学会雑誌 67 (5): 597-640, 1991
Tanaka T, Yoshizawa A, Tanae A, Hibi I, Shizume K.:
Relationdhips between puberty and growth at adolescence in growth-hormone-deficient males:
Effect of growth hormone and of associated gonadal suppression therapy.
Horm Res 33 (suppl 4) : 102-105, 1990
Hibi I, Tanaka T, Tanae A, Kagawa J, Hashimoto N, Yoshizawa A, Shizume K.:
The influence of gonadal function and the effect of gonadal suppression treatment on final height in growth hormone (GH)-treated GH-deficient children.
J Clin Endocrinol Metab 69: 221-226, 1989
Hibi I, Tanaka T and Committee for Treatment of Growth Hormone Dficient Children, Growth Science Foundation:
Final height of patients with idiopathic growth hormone deficiency after long-term growth hormone treatment.
Acta Encodrinologica 120: 409-415, 1989
Hibi I, Tanae A, Kagawa J, Hashimoto N, Tanaka T, Shizume K.:
Influence of gonadal function on final height in hGH-treated GH-deficient children.
Acta Paediatrica Japonica 30: 39-42, 1988
【研究論文】
Kunihiko Hanew, Toshiaki Tanaka, Reiko Horikawa, Tomonobu Hasegawa, Susumu Yokoya:
The current status of 492 adult women with Turner syndrome: a questionnaire survey by the Foundation for Growth Science.
Endocr J 68 (9):1081-1089,2021
Kunihiko H, Toshiaki T, Reiko H, Tomonobu H, Susumu Y,:
Prevalence of diverse complications and its association with karyotypes in Japanese adult women with Turner syndrome－a questionnaire survey by the Foundation for Growth Science－
Endocr J 65(5): 509-519, 2018
Kunihiko Hanew, Toshiaki Tanaka, Reiko Horikawa, Tomonobu Hasegawa, Keinosuke Fujita, Susumu Yokoya:
Women with Turner syndrome are at high risk of lifestyle-related disease ― From questionnaire surveys by the Foundation for Growth Science in Japan
Endocrine Journal 63 (5), 449-456, 2016
Eri Maeda, Takahiro Higashi, Tomonobu Hasegawa, Susumu Yokoya, Takahiro Mochizuki, Tomohiro Ishii, Junko Ito, Susumu Kanzaki, Akira Shimatsu, Koji Takano, Toshihiro Tajima, Hiroyuki Tanaka, Yusuke Tanahashi, Akira Teramoto, Toshiro Nagai, Kunihiko Hanew, Reiko Horikawa, Toru Yorifuji, Naohiro Wada and Toshiaki Tanaka:
Effects of financial support on treatment of adolescents with growth hormone deficiency: a retrospective study in Japan
BMC Health Services Research (2016) 16:602
望月貴博、石井智弘、伊藤純子、神崎 晋、島津 章、高野幸路、田島敏広、田中弘之、棚橋祐典、寺本 明、永井敏郎、羽二生邦彦、東 尚弘、堀川玲子、横谷 進、依藤 亨、和田尚弘、長谷川奉延、田中敏章：
成長ホルモン治療中のターナー症候群におけるエストロゲン補充療法の治療実態と開始時期の基準に
ついて
日本成長学会雑誌 22 No.1: 43-47, 2016
Fujita K, Yokoya S, Fujieda K, Shimatsu A, Tachibana K, Tanaka H, Tanizawa T, Teramoto A, Nishi Y, Hasegawa Y, Hanew K, Horikawa R, Nagai T, Tanaka T.:
Adult height of 258 girls with Turner syndrome on low dose of growth hormone therapy in Japan.
Clin Pediatr Endocrinol 19(3): 63-68, 2010
田中敏章、伊藤純子、神崎 晋、島津 章、田中弘之、寺本 明、永井敏郎、長谷川奉延、羽二生邦彦、藤田敬之助、堀川玲子、向井徳男、和田尚弘、横谷 進：
成長ホルモン分泌不全性低身長症における成長ホルモンによる前思春期の治療開始年齢別治療効果
日本成長学会雑誌 16: 23-29, 2010
Isojima T, Yokoya S, Ito J, Horikawa R, Tanaka T.:
New reference growth charts for Japanese girls with Turner syndrome.
Pediatrics International 51: 709-714, 2009
Isojima T, Yokoya S, Ito J, Horikawa R, Tanaka T.:
Trends in age and anthropometric data at start of growth hormone treatment for girls with Turner syndrome in Japan.
Endocr J 55(6): 1065-1070, 2008
田中敏章、伊藤純子、島津 章、田中弘之、寺本 明、永井敏郎、長谷川奉延、羽二生邦彦、藤田敬之助、堀川玲子、向井徳男、和田尚弘、横谷 進：
年齢別およびSGA児とAGA児における成長ホルモン治療の一年目の効果の比較
日本成長学会雑誌14: 25-30, 2008
Hanew K, Tachibana K, Yokoya S, Fujieda K, Tanaka T, Igarashi Y, Shimatsu A, Tanaka H, Tanizawa T, Teramoto A, Nishi Y, Hasegawa Y, Hizuka N, Hirano T, Fujita K, GH treatment Study Committee, The Foundation for Growth Science, Japan.:
Clinical characteristics, etiologies and pathophysiology of patients with severe short stature with sever GH deficiency: Questionnaire study on the data registered with the Foundation for Growth Science, Japan.
Endocr J 53: 259-265, 2006
Tanaka T, Fujieda K, Yokoya S, Shimatsu A, Tachibana K, Tanaka H, Tanizawa T, Teramoto A, Nagai T, Nishi Y, Hasegawa Y, Hanew K, Fujita K, Horikawa R, Takada G, Miyashita M, Ohno T, Komatsu K.:
No inprobement of adult height in non-growth hormone (GH) deficient short children with GH treatment.
Clin Pediatr Endocrinol 15: 15-21, 2006
Hanew K, Tachibana K, Yokoya S, Fujieda K, Tanaka T, Igarashi Y, Shimatsu A, Tanaka H, Tanizawa T, Teramoto A, Nishi Y, Hasegawa Y, Hizuka N, Hirano T, Fujita K.:
Studies of very severe shot stature with severe GH deficiency: From the data registered with the Foundation for Growth Science.
Endocr J 52: 37-43, 2005
田中敏章、藤枝憲二、羽二生邦彦、西 美和、立花克彦、横谷 進、五十嵐裕、平野岳毅、藤田敬之助、寺本 明、肥塚直美、島津 章、田中弘之、谷澤隆邦、長谷川行洋：
成長ホルモン分泌不全性低身長症における遺伝子組換え成長ホルモン治療による最終身長の正常化の割合
日本小児科学会雑誌105: 546-551, 2001
Tanaka T, Hanew K, Nishi Y, Tachibana K, Yokoya S, Igarashi Y, Hirano T, Fujita K, Saito T, Hizuka N, Shimatsu A, Tanaka H, Tanizawa T, Teramoto A, Fujieda K.:
Final height of growth hormone (GH)-treated short children registered at the Foundation for Growth Science in Japan: Comparison between the pituitary human GH era and the recombinant human GH era.
Clin pediatr Endocrinol 10 (1): 53-62, 2001
Tanaka T, Takano K, Ogawa M, Tachibana K, Fujieda K, Hizuka N and the members of Study Groups of GH treatment of Turner syndrome:
Final height in Turner syndrome after growth hormone treatment: Japanese study.
Optimizing Health Care for Turner Patients in the 21st Century (eds. Saenger P, Albertsson-Wikland K),
Elsevier Science B.V., Amsterdam, pp223-228, 2000
Takano K, Tanaka T, Ogawa M, Tachibana K, Fujita K, Hizuka N and Members of the Committee for the Treatment of Turnerﾕs Syndrome:
Clinical outcome of GH treatment in Turner girls in Japan: results of multicentre trial.
Clin Pediatr Endocrinol 9 (suppl 14): 15-22, 2000
田中敏章、高野和寿恵、羽二生邦彦、西 美和、藤枝憲二、立花克彦、横谷 進、五十嵐裕、平野岳毅、肥塚直美、島津 章、齋藤友博、藤田敬之助：
成長ホルモン分泌不全性低身長症の成長ホルモン治療の頻度－成長科学協会における登録の解析－
ホルモンと臨床 46：1017-1023, 1998
Takano K, Ogawa M, Tanaka T. Tachibana K, Fujita K, Hizuka N.:
Final height in patients with Turner syndrome after treatment with GH.
Clin Pediatr Endocrinol 6 (suppl 10): 51-57, 1997
Takano K, Ogawa M, Tanaka T. Tachibana K, Fujieda K, Hizuka N, and the Members of the Committee for the Treatment of Turnerﾕs Syndrome:
Clinical trials of GH treatment in patients with Turnerﾕs syndrome in Japan-a consideration of final height.
Eur J Endocrinol. 137: 138-145, 1997
Tanaka T. Takano K, Hanew K, Nishi Y, Fujieda K, Tachibana K, Yokoya S, Igarashi Y, Hirano T.:
Spontaneous growth in growth hormone-treated short children.
Endocr J 43 (suppl): S135-S136, 1996
藤枝憲二、田中敏章、立花克彦、高野和寿恵、西 美和、佐々木望、矢野公一、岡部康文、岩松浩子、滝沢鷹太郎、宇佐見郁哉、大元習子、千葉喜代志、伊賀和夫、番場正博：
成長ホルモン療法を行っている糖尿病患者の実態調査
日本小児科学会雑誌100（5）：877-881, 1996
Takano K, Tanaka T, Saito T, the Committee for the Study Group of Adult GH Deficiency:
Psychosocial adjustment in a large cohort adults with growth hormone deficiency treated with growth hormone in childhood: summary of a questionnaire survey.
Acta Pediatr (suppl) 339: 16-19, 1994
Takano K, Tanaka T, Saito T, the Member of the Committee:
Psychosocial consequences of growth hormone deficiency (GHD) in adults.
Clin Pediatr Endocrinol 3 (suppl 5): 79-86, 1994
Takano K, Tanaka T, Saito T, the Members of the Committee of the Study Group for Adult GH Deficiency, Foundation for Growth Science in Japan:
Quality of the life growth hormone treated adults.
Clin Pediatr Endocrinol 3 (suppl 4): 47-53, 1994
Takano K, Shizume K, Hibi I, Ogawa M, Okada Y, Suwa S, Tanaka T, and Members of the Committee for the Treatment of Turner Syndrome:
Growth hormone treatment in Turner syndrome: Results of a multicentre study in Japan.
Home Res 39 (suppl 2): 37-41,1993
田中敏章、日比逸郎、鎮目和夫、Turner症候群GH治療研究会員:
Turner症候群における成長ホルモン（GH）分泌能とGH治療効果の検討－下垂体性小人症との比較－
日本内分泌学会雑誌 67 (5): 597-640, 1991
Tanaka T, Yoshizawa A, Tanae A, Hibi I, Shizume K.:
Relationdhips between puberty and growth at adolescence in growth-hormone-deficient males:
Effect of growth hormone and of associated gonadal suppression therapy.
Horm Res 33 (suppl 4) : 102-105, 1990
Hibi I, Tanaka T, Tanae A, Kagawa J, Hashimoto N, Yoshizawa A, Shizume K.:
The influence of gonadal function and the effect of gonadal suppression treatment on final height in growth hormone (GH)-treated GH-deficient children.
J Clin Endocrinol Metab 69: 221-226, 1989
Hibi I, Tanaka T and Committee for Treatment of Growth Hormone Dficient Children, Growth Science Foundation:
Final height of patients with idiopathic growth hormone deficiency after long-term growth hormone treatment.
Acta Encodrinologica 120: 409-415, 1989
Hibi I, Tanae A, Kagawa J, Hashimoto N, Tanaka T, Shizume K.:
Influence of gonadal function on final height in hGH-treated GH-deficient children.
Acta Paediatrica Japonica 30: 39-42, 1988